Progress in Computational Studies of Host-pathogen Interactions

Editorial: Computational Systems Biology of Pathogen-Host Interactions

Pathogen-Host Interactions (PHIs) play a significant role in the mechanisms of infections. Therefore, the investigation of infectionmechanisms through PHIs is a crucial step to develop novel and more effective solutions against drug-resistance and for personalized therapy. To this aim, systems biology approach considers the whole PHI system instead of focusing hosts or pathogens individually. C...

Facing the challenges of multiscale modelling of bacterial and fungal pathogen–host interactions

Recent and rapidly evolving progress on high-throughput measurement techniques and computational performance has led to the emergence of new disciplines, such as systems medicine and translational systems biology. At the core of these disciplines lies the desire to produce multiscale models: mathematical models that integrate multiple scales of biological organization, ranging from molecular, c...

Host pathogen protein interactions predicted by comparative modeling.

Pathogens have evolved numerous strategies to infect their hosts, while hosts have evolved immune responses and other defenses to these foreign challenges. The vast majority of host-pathogen interactions involve protein-protein recognition, yet our current understanding of these interactions is limited. Here, we present and apply a computational whole-genome protocol that generates testable pre...

Computational Studies of Host-Pathogen Protein-Protein Interactions

Mathematical and computational approaches can complement experimental studies of host-pathogen interactions.

In addition to traditional and novel experimental approaches to study host-pathogen interactions, mathematical and computer modelling have recently been applied to address open questions in this area. These modelling tools not only offer an additional avenue for exploring disease dynamics at multiple biological scales, but also complement and extend knowledge gained via experimental tools. In t...